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10.1016/j.kint.2020.06.034 42 EspositoE.LiW.ET

Although the hypothalamic median eminence lacks a blood-brain barrier, only small amounts of CGRP-mAbs cross the bloodbrain barrier [25]

Notably, the cytoplasmic C-terminal tail of ZnT1 alone can inhibit the channel, suggesting that the inhibition of L-type calcium channels by ZnT1 is independent of zinc channel function

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They have protective roles in regulating the bioavailability, metabolism, distribution, and excretion of xenobiotics, detoxified drug conjugates and endogenous metabolites 25